Europe: Vanishing Mediator

Looking at vanishing treatment effect in Europe.

Assertive community treatment: keeping what works The excellent editorial by Rosen et al highlights the dilution of assertive community treatment (ACT) research in European settings, leading to a failure to demonstrate reductions in bed use in efficacy studies. Effectiveness studies in the UK have shown that ACT leads to reductions in bed use. Furthermore, our experience of 93 patients followed...

Hepatitis delta in Europe: vanishing or refreshing?

Vanishing Vanishing Cycles

If A• is a bounded, constructible complex of sheaves on a complex analytic space X, and f : X → C and g : X → C are complex analytic functions, then the iterated vanishing cycles φg[−1](φf [−1]A •) are important for a number of reasons. We give a formula for the stalk cohomology H∗(φg[−1]φf [−1]A •)x in terms of relative polar curves, algebra, and the normal Morse data and micro-support of A•.

Vanishing Canadians.

Take a look around at your fellow Canadians, because they are slowly disappearing. All of the scenarios projected by Statistics Canada about population growth in Canada over the next 50 years show a “negative increase” (you’ve got to love bureaucratic language) in the number of births minus deaths.1 In the low-growth scenario for the Canadian population, the first year in which there will be mo...

Vanishing biodiversity.

Background: Drug-metabolizing enzymes play a role in chemical carcinogenesis through enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene polymorphisms of several cytochrome P450 enzymes in digestive cancer risk has been extensively investigated. However, the drug-metabolizing enzymes with the broader substrate specificity, CYP3A4 and CYP3A5, have not be...